The popularity of GLP-1s antagonists is growing at an incredible rate all over the world. The demand is so high that millions of dollars have been spent trying to find all-natural plant-based substances to mimic the mechanism of action of these drugs. GLP-1s are medications that mimic the effects of a naturally occurring hormone in the body, GLP-1, to help regulate blood sugar levels and promote weight loss. They work by stimulating insulin release, suppressing glucagon, slowing digestion, and increasing feelings of fullness.
At MacroLife Naturals, it is our mission to create synergistic formulas that help us live longer to get the most out of life. We transformed this passion into creating our family company after its founder Sylvia Ortiz created Macro Greens in 1998. Sylvia was on a quest to help her son regain his health and cut down the cost and headache of taking 30-40 tablets and capsules a day. After seeing her son JR’s success in trimming down 65 lbs. and getting his digestion and food cravings under control. JR & Sylvia decided to dive deep into researching natural ways to feed the body at the cellular level and produce an environment for multiple systems to thrive. Essentially, we were taking a “Macro” view to health and wellness. This is how MacroLife Naturals was formed 25+ years ago.
In doing the research Sylvia, JR, and a Wholestic team formulated the most comprehensive set of superfood and protein powders for the whole family. It is incredible to see that traditional science is proving without a doubt that the right blend of ingredients can have long-term benefits no matter the age your health journey starts.
For GLP-1s, the recent research is showing that resveratrol in the right amount per day can increase the total amount of GLP-1 hormone in the blood system however, the test subjects did not report any cognitive effect or measurable overall results by adding one ingredient to the diet. The same limited cognitive were observed when adding the following extracts to the diet separately; green tea extract, curcumin, capsaicin (red pepper extract) among a few others. By adding prebiotics, probiotics into Macro Greens and Miracle Reds it created the best environment possible for efficacy. Thus, bringing us to the conclusion that the body would respond to a synergistic combination of these specific ingredients that naturally increase GLP-1 peptides in the blood stream.
On paper, formulating products that work should be relatively easy if you follow indisputable scientific evidence. The tough part is to make sure that the “active” compound(s) that need to reach a specific destination in the gut or in the bloodstream gets there effectively. This is why all MacroLife products contain pre & probiotics as they are commonly catalysts and or co-factor (nutritional chaperone) for many vitamins, minerals, antioxidants, including hormone production.
MacroLife’s first product was Macro Greens to a handful of Naturals Food Stores and Wholistic & Naturopathic Doctors in 1998. Most customers at that time would be called “Hippies” or what we call it now being a “Almonds.” Regardless of the name, the connection is that these consumers attempt to live as clean and healthy as possible to enjoy everything the world has the offer. In that spirit, Macro Greens contains 18 billion probiotics, natural prebiotics from apple pectin/fiber, Green Tea extract, along with Aloe Vera, and acerola berry extract to help deliver the right nutrients to the place they need to go.
Choose the original Macro Greens superfood when you are ready to jump start your weight and wellness journey. You will be surprised at how delicious natures superfoods can be. That’s why, we say “Add a little to your DAY… Live a MacroLife!”
References:
✅ Resveratrol Effects in Humans & Other Models
- In high-fat diet mice, resveratrol supplementation tripled the active GLP‑1 concentrations in the portal vein, improved glucose tolerance, and raised insulin levels. GLP‑1 receptor knockout mice did not benefit—highlighting GLP‑1 as the mediator of resveratrol’s effects Reddit+15frontiersin.org+15Reddit+15.
- In obese human males, 30 days of 150 mg/day resveratrol supplementation did not change fasting or postprandial GLP‑1 levels—but did significantly suppress postprandial glucagon (p = 0.01) PubMed+1.
- Review articles note that while resveratrol may modulate GLP‑1 via gut‑brain axis pathways and microbiota regulation, its direct effect on GLP‑1 release in humans remains controversial PMC+2PubMed+2.
✅ Curcumin, Capsaicin & Green Tea Extract (Limited Evidence on GLP‑1)
- Curcumin supplementation (70–2400 mg/day over 4–36 weeks) in metabolic syndrome patients significantly reduced body weight, BMI, waist circumference and improved metabolic parameters—but GLP‑1 levels were not assessed directly verywellhealth.com.
- Capsaicin (≈6 mg/day) in humans over 12 weeks showed mild reductions in BMI and appetite, but no direct GLP‑1 data exists; evidence in humans is limited and mostly negative or inconclusive verywellhealth.com.
- Green tea extract is widely used, but trials rarely measure GLP‑1. Evidence suggests weight benefit via metabolism or satiety pathways, not proven via GLP‑1 modulation in clinical studies.
